Research Areas

Enzymatic catalysis，Nanobiotechnology，Biosensing，Biomedicine.

Highlights

To meet the need of key biocatalysis technologies which have been applied in different  fields like biomedicine, biosafety, medical diagnosis and so on, thinking about the scientific frontier of the fusion of biocatalysis and chemical catalysis, Prof. Ge proposed "catalyst editing" as the core the research direction of enzyme catalyst engineering, and constructed high-efficiency biochemical compound catalyst with multi-scale interaction mechanism, which solves the common basic problems of incompatibility, difficulty and low efficiency in the bio-chemical cascade reaction.

Prof. Ge has published over 60 papers in scientific journals, including Nature Nanotechnology, Nature Catalysis, Nature Communications, Science Advances, Nano Letters, ACS Nano, ACS Catalysis. 

Honors

MIT Technology Review World 35 Innovators Under 35 

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2. MIT Technology Review | World 35 Innovators Under 35

Selected Publications

1. Cao, Y.; Li,X.; Ge, J.* Enzyme catalyst engineering toward the integration of biocatalysis and chemocatalysis. Trends in Biotechnology 2021, 4. DOI: 10.1016/j.tibtech.2021.01.002.

2. Hu, C.#; Bai, Y.#; Hou, M.; Wang, Y.; Wang, L.; Cao, X.; Chan, C.-W.; Sun, H.; Li, W.; Ge, J.*; Ren, K.*. Defect-induced activity enhancement of enzyme-encapsulated metal-organic frameworks revealed in microfluidic gradient mixing synthesis. Science Advances 2020, 6, eaax5785.

3. Wu, X.#; Yue, H.#; Zhang, Y.#; Gao, X.; Li, X.; Wang, L.; Cao, Y.; Hou, M.; An, H.; Gu, H.; Zhang, L.*; Li, S.*; Lou, W.; Ma, J.; Lin, H.; Fu, Y.; Wei, W.*; Zare, R. N.; Ge, J.* Packaging and delivering enzymes by amorphous metal-organic frameworks. Nature Communications. 2019, 10, 5165.

4. Li, X. #; Cao, Y. #; Luo, K. #; Sun, Y.; Xiong, J.; Wang, L.; Liu, Z.; Li, J.; Ma, J.; Ge, J.*; Xiao, H.*; Zare, R. N.* Highly active enzyme-metal nanohybrids synthesized in protein-polymer conjugates. Nature Catalysis 2019, 2, 718-725.

5. Ge, J.#; Lei, J.#; Zare, R. N.* Protein-inorganic hybrid nanoflowers. Nature Nanotechnology 2012, 7, 428-432.