科学研究

科学研究

科学研究

Artem Efremov

汇天下英才 建世界舞台

Artem Efremov

系统与物理生物学研究所

特聘研究员

artem@szbl.ac.cn

Timeline

  • 2020-Now

    Shenzhen Bay Laboratory         Principal investigator

  • 2013

    Mechanobiology Institute, National University of Singapore         Senior postdoctoral research fellow

  • 2011

    Rice University         Postdoctoral research fellow

  • 2009

    National University of Singapore and Singapore-MIT Alliance for Research and Technology (S.M.A.R.T.)         Postdoctoral research fellow

  • 2008

    Moscow State University         Ph.D. degree (Ph.D. in physics, specialization: biophysics)

  • 2004

    Moscow State University         Graduate study

  • 1998

    Moscow State University         Undergraduate study









Research Areas


• Study of molecular mechanisms responsible for mechanotransduction in living cells.

• Understanding the role of mechanical and topological constraints in regulation of DNA-protein interactions and chromatin organization in living cells.

• Exploration of molecular mechanisms underlying mechanochemical coupling in cytoskeletal motor proteins, and their role in regulation of intracellular transportation.

• Development and application of single-molecule force-spectroscopy methods for investigation of the above questions.


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Achievements


During past several years Artem has been applying various experimental and theoretical biophysical methods, such as optical and magnetic tweezers, confocal and atomic force microscopy as well as elements of chemical kinetics and quantum physics theories, to explore different biological systems at molecular level ranging from kinesin and myosin motor proteins to DNA-architectural complexes. These researches done in collaboration with world leading biophysical groups led to several interesting discoveries and practical implications such as construction of light-driven nano-motors and development of experimental assays, which can be used for investigation of human-related neural and parasitic diseases at single-molecule level. Artem’s work has been published in many high impact journals including Cell, PNAS, Nature Communications and Nucleic Acids Research. He has been a member of American Biophysical Society and Australian Society for Biophysics since 2015 and 2017, respectively.






Current Openings


1. Postdoc

2. Research Assistant







5 Selected Publications 


  1. 1. M. I. Molodtsov, E. L. Grishchuk, A. K. Efremov, J. R. McIntosh, F. I. Ataullakhanov. 2005. Force production by depolymerizing microtubules: a theoretical study. Proc. Natl. Acad. Sci. USA, 102:4353-8.[F1000 recommendation]Web-link: http://www.pnas.org/content/102/12/4353

2. Artem Efremov, Ekaterina L. Grishchuk, J. Richard McIntosh, Fazly I. Ataullakhanov. 2007. In search of an optimal ring to couple microtubule depolymerization to processive chromosome motions. Proc. Natl. Acad. Sci. USA, 104:19017-22.Web-link: http://www.pnas.org/content/104/48/19017

3. E. L. Grishchuk, I. S. Spiridonov, V. A. Volkov, A. Efremov, S. Westermann, D. Drubin, G. Barnes, F. I. Ataullakhanov, and J. R. McIntosh. 2008. Different assemblies of the DAM1 complex follow shortening microtubules by distinct mechanism. Proc. Natl. Acad. Sci. USA, 105:6918-23.[F1000 recommendation]Web-link: http://www.pnas.org/content/105/19/6918

4. J. R. McIntosh, E. L. Grishchuk, M. Morphew, A. K. Efremov, K. Zhudenkov, V. Volkov, I. Cheeseman, A. Desai, D. N. Mastronarde, F. I. Ataullakhanov. 2008. Fibrils connect microtubule tips with kinetochores: a mechanism to couple tubulin dynamics to chromosome motion. Cell, 135:322-33.[F1000 recommendation]Web-link: https://www.cell.com/cell/fulltext/S0092-8674(08)01119-7

5. Ekaterina L. Grishchuk, Artem K. Efremov, Vladimir A. Volkov, Ilia S. Spiridonov, Nikita Gudimchuk, Stefan Westermann, David Drubin, Geojana Barnes, J. Richard McIntosh, and Fazly I. Ataullakhanov. 2008. The Dam1 ring binds microtubules strongly enough to be a processive as well as energy-efficient coupler for chromosome motion. Proc. Natl. Acad. Sci. USA, 105:15423-8.Web-link: http://www.pnas.org/content/105/40/15423






Personal Websites


1) Google Scholar: https://scholar.google.com/citations?user=DHS_uKEAAAAJ&hl=en

2) Researchgate: https://www.researchgate.net/profile/Artem_Efremov