Shenzhen Bay Laboratory Principal investigator
Mechanobiology Institute, National University of Singapore Senior postdoctoral research fellow
Rice University Postdoctoral research fellow
National University of Singapore and Singapore-MIT Alliance for Research and Technology (S.M.A.R.T.) Postdoctoral research fellow
Moscow State University Ph.D. degree (Ph.D. in physics, specialization: biophysics)
Moscow State University Graduate study
Moscow State University Undergraduate study
• Study of molecular mechanisms responsible for mechanotransduction in living cells.
• Understanding the role of mechanical and topological constraints in regulation of DNA-protein interactions and chromatin organization in living cells.
• Exploration of molecular mechanisms underlying mechanochemical coupling in cytoskeletal motor proteins, and their role in regulation of intracellular transportation.
• Development and application of single-molecule force-spectroscopy methods for investigation of the above questions.
During past several years Artem has been applying various experimental and theoretical biophysical methods, such as optical and magnetic tweezers, confocal and atomic force microscopy as well as elements of chemical kinetics and quantum physics theories, to explore different biological systems at molecular level ranging from kinesin and myosin motor proteins to DNA-architectural complexes. These researches done in collaboration with world leading biophysical groups led to several interesting discoveries and practical implications such as construction of light-driven nano-motors and development of experimental assays, which can be used for investigation of human-related neural and parasitic diseases at single-molecule level. Artem’s work has been published in many high impact journals including Cell, PNAS, Nature Communications and Nucleic Acids Research. He has been a member of American Biophysical Society and Australian Society for Biophysics since 2015 and 2017, respectively.
5 Selected Publications
1. M. I. Molodtsov, E. L. Grishchuk, A. K. Efremov, J. R. McIntosh, F. I. Ataullakhanov. 2005. Force production by depolymerizing microtubules: a theoretical study. Proc. Natl. Acad. Sci. USA, 102:4353-8.[F1000 recommendation]Web-link: http://www.pnas.org/content/102/12/4353
2. Artem Efremov, Ekaterina L. Grishchuk, J. Richard McIntosh, Fazly I. Ataullakhanov. 2007. In search of an optimal ring to couple microtubule depolymerization to processive chromosome motions. Proc. Natl. Acad. Sci. USA, 104:19017-22.Web-link: http://www.pnas.org/content/104/48/19017
3. E. L. Grishchuk, I. S. Spiridonov, V. A. Volkov, A. Efremov, S. Westermann, D. Drubin, G. Barnes, F. I. Ataullakhanov, and J. R. McIntosh. 2008. Different assemblies of the DAM1 complex follow shortening microtubules by distinct mechanism. Proc. Natl. Acad. Sci. USA, 105:6918-23.[F1000 recommendation]Web-link: http://www.pnas.org/content/105/19/6918
4. J. R. McIntosh, E. L. Grishchuk, M. Morphew, A. K. Efremov, K. Zhudenkov, V. Volkov, I. Cheeseman, A. Desai, D. N. Mastronarde, F. I. Ataullakhanov. 2008. Fibrils connect microtubule tips with kinetochores: a mechanism to couple tubulin dynamics to chromosome motion. Cell, 135:322-33.[F1000 recommendation]Web-link: https://www.cell.com/cell/fulltext/S0092-8674(08)01119-7
5. Ekaterina L. Grishchuk, Artem K. Efremov, Vladimir A. Volkov, Ilia S. Spiridonov, Nikita Gudimchuk, Stefan Westermann, David Drubin, Geojana Barnes, J. Richard McIntosh, and Fazly I. Ataullakhanov. 2008. The Dam1 ring binds microtubules strongly enough to be a processive as well as energy-efficient coupler for chromosome motion. Proc. Natl. Acad. Sci. USA, 105:15423-8.Web-link: http://www.pnas.org/content/105/40/15423
1) Google Scholar: https://scholar.google.com/citations?user=DHS_uKEAAAAJ&hl=en
2) Researchgate: https://www.researchgate.net/profile/Artem_Efremov