Nucleus size and its effect on nucleosome stability in living cells

2022-11-03

Nucleus size and its effect on nucleosome stability in living cells

This effect has been found to have a profound impact on stability of nucleosomes, revealing a previously unknown link between the nucleus size and chromatin structure. Overall, our study provides new insights into the molecular mechanisms responsible for regulation of the nucleus size, as well as the potential role of nuclear organization in shaping the cell response to environmental cues.

Neighboring mutation-mediated enhancement of dengue virus infectivity and spread

2022-10-12

Neighboring mutation-mediated enhancement of dengue virus infectivity and spread

Accordingly, we predict that a G228E substitution could potentially result in a forthcoming epidemic of the DENV2 Cosmopolitan genotype. Investigations into the substitutions associated with DENV fitness in hosts may offer mechanistic insights into dengue prevalence, thus providing a warning of potential epidemics in the future.

A Peptide-Based Ligand-Directed Chemistry Enables Protein Functionalization

2022-10-10

A Peptide-Based Ligand-Directed Chemistry Enables Protein Functionalization

The ligand-directed (LD) chemistry provides powerful tools for site-specific modification of proteins. We utilized a peptide with an appended methionine (Met) as a ligand; then, the Met thioether was modified into sulfonium which enabled a proximity induced group transfer onto protein cysteine in the vicinity upon peptide–target binding. The sulfonium warhead could be easily constructed with unprotected peptides, and the transferable group scope was conducted on model protein PDZ and its ligand peptides. In addition, a living cell labeling was successfully achieved.

Association of Presynaptic Loss with Alzheimer's Disease and Cognitive Decline

2022-09-19

Association of Presynaptic Loss with Alzheimer's Disease and Cognitive Decline

Tau aggregations rather than Aβ plaques primarily drive presynaptic dysfunction measured by CSF GAP43, which may lead to sequential neurodegeneration and cognitive impairment in AD or neurodegenerative diseases.

Motor learning-induced new dendritic spines are preferentially involved in the learned task than existing spines

2022-09-19

Motor learning-induced new dendritic spines are preferentially involved in the learned task than existing spines

These findings suggest that newly formed synapses preferentially increase the task specificity of neurons over existing synapses at the retention stage of motor learning.

Structure-Based Design, Optimization, and Evaluation of Potent Stabilized Peptide Inhibitors Disrupting MTDH and SND1 Interaction

2022-09-09

Structure-Based Design, Optimization, and Evaluation of Potent Stabilized Peptide Inhibitors Disrupting MTDH and SND1 Interaction

To date, our study was the first report to demonstrate that stabilized peptides truncated from MTDH could serve as promising candidates to disrupt the MTDH/SND1 interaction for potential breast cancer treatment.