Research Areas

Yulong Li's research group is committed to researching cutting-edge scientific issues in the field of neurobiology. His research work mainly includes the following aspects:

1. Development of genetically-encoded sensors for imaging neurotransmitters/ modulators and mapping electric synapses.

2. Deorphanization of orphan G protein coupled receptors (GPCRs) in the nervous system.

3. Development of genetically-encoded tags for multiple cell type labeling in the brain under in vivo and EM system.

Selected Publications

1. Jing, M. *, Zhang, P. *, Wang, G., Feng, J., ... Zhu, JJ. # & Li, Y. # (2018). A genetically-encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. Nature Biotechnology, 36(8), 726-737.

2. Sun, F. *, Zeng, J. *, Jing, M. *, Zhou, J., Feng, J., ... & Li, Y. # (2018). A genetically-encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice. Cell, 174(2), 481-496.

3. Feng, J., Zhang, C., Lischinsky, JE., Jing, M., ... & Li, Y. # (2019). A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine. Neuron, 102(4), 745-761

4. Wu, L., Dong, A., Dong, L., Wang, S. Q., & Li, Y. # (2019). PARIS, an optogenetic method for functionally mapping gap junctions. eLife, 8, e43366

5. Yu, H., Zhao, T., Liu, S., Wu, Q., Johnson, O., Wu, Z., Zhuang, Z., Shi, Y., He, R., Yang, Y., Sun, J., Wang, X., Xu, H., Zeng, Z., Lei, X., Luo, W.*, & Li, Y.* (2019). MRGPRX4 is a bile acid receptor for human cholestatic itch. eLife