2023 - 至今
深圳医学科学院　特聘研究员

2019 - 2023
清华大学　生命科学院　副研究员

2016 - 2019
清华大学　医学院　博士后

2011 - 2016
清华大学　医学院　博士

2007 - 2011
中国科学技术大学　生命科学院　学士

主要运用结构生物学、生物化学、生理学等手段，从事与重大疾病相关的膜蛋白的工作机理和药物作用机制的研究，目前开展的方向包括代谢疾病相关的膜蛋白以及肿瘤-免疫相关的蛋白的研究。潘孝敬博士在国际顶级学术期刊Science上以第一作者（含共一）发表文章5篇，以共通讯作者在PNAS，Nature Communications等杂志发表文章7篇。

2021 中国博士后基金会优秀创新成果

2019 北京市科委评选“科技新星”

2019 清华大学结构生物学高精尖中心卓越青年科学家

2018 清华大学优秀博士后

2016 中国博士后基金会“博新计划”

2016 北京市优秀毕业生

2013 教育部博士生国家奖学金

2012 教育部硕士生国家奖学金

2012 教育部第十七届博士生学术新人奖

2012 清华大学“蒋南翔”奖学金

2011 安徽省优秀毕业生，中国科学技术大学优秀毕业生

*代表共同第一作者，#代表共同通讯作者。

1.Wu, Q.^*, Huang, J.^*#, Fan, X.^*#, Wang, K.^*, Jin, X., Huang, G., Li, J.,Pan, X.^#and Yan, N.^#, 2023. Structural mapping of Nav1. 7 antagonists.Nature Communications,14(1), p.3224.

2.Huang, G.^*, Wu, Q.^*, Li, Z.^*, Jin, X.^*, Huang, X., Wu, T.,Pan, X.^#and Yan, N.^#, 2022. Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Nav1. 7.Proceedings of the National Academy of Sciences,119(33), p.e2209164119.

3.Huang, X.^*, Jin, X.^*, Huang, G., Huang, J., Wu, T., Li, Z., Chen, J., Kong, F.,Pan, X.^#and Yan, N.^#, 2022. Structural basis for high-voltage activation and subtype-specific inhibition of human Nav1. 8.Proceedings of the National Academy of Sciences,119(30), p.e2208211119.

4.Pan, X.^*#, Li, Z.^*, Jin, X.^*, Zhao, Y.^*, Huang, G.^*, Huang, X., Shen, Z., Cao, Y., Dong, M., Lei, J. and Yan, N.^#, 2021. Comparative structural analysis of human Nav1. 1 and Nav1. 5 reveals mutational hotspots for sodium channelopathies.Proceedings of the National Academy of Sciences,118(11), p.e2100066118.

5.Li, Z., Jin, X., Wu, T., Zhao, X., Wang, W., Lei, J.,Pan, X.^#and Yan, N.^#, 2021. Structure of human Nav1. 5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome.Proceedings of the National Academy of Sciences,118(11), p.e2100069118.

6.Shen, H.^#, Yan, N.^#andPan, X.^#, 2021. Structural determination of human Nav1. 4 and Nav1. 7 using single particle cryo-electron microscopy.Methods in Enzymology(Vol. 653, pp. 103-120). Academic Press.

7.Chi, X.^*, Jin, X.^*, Chen, Y.^*, Lu, X., Tu, X., Li, X., Zhang, Y., Lei, J., Huang, J., Huang, Z.^#, Zhou, Q.^#, andPan, X.^#, 2020. Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence.Cell Discovery,6(1), p.55.

8.Pan, X.^*, Li, Z.^*, Huang, X.^*, Huang, G.^*, Gao, S., Shen, H., Liu, L., Lei, J. and Yan, N., 2019. Molecular basis for pore blockade of human Na+ channel Nav1. 2 by the μ-conotoxin KIIIA.Science,363(6433), pp.1309-1313.

9.Pan, X.^*, Li, Z.^*, Zhou, Q.^*, Shen, H.^*, Wu, K.^*, Huang, X., Chen, J., Zhang, J., Zhu, X., Lei, J. and Xiong, W., Gong, H., Xiao, B., and Yan, N., 2018. Structure of the human voltage-gated sodium channel Nav1. 4 in complex with β1.Science.362(6412), p.eaau2486.

10.Shen, H.^*, Li, Z.^*, Jiang, Y.^*,Pan, X.^*, Wu, J., Cristofori-Armstrong, B., Smith, J.J., Chin, Y.K., Lei, J., Zhou, Q.^#and King, G.F.^#, and Yan, N.^#, 2018. Structural basis for the modulation of voltage-gated sodium channels by animal toxins.Science,362(6412), p.eaau2596.

11.Shen, H.^*, Zhou, Q.^*,Pan, X.^*, Li, Z.^*, Wu, J. and Yan, N., 2017. Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution.Science,355(6328), p.eaal4326.

12.Deng, D.^*, Yan, C.^*,Pan, X.^*, Mahfouz, M., Wang, J., Zhu, J.K., Shi, Y.^#and Yan, N.^#, 2012. Structural basis for sequence-specific recognition of DNA by TAL effectors.Science,335(6069), pp.720-723.