2021 至今  
深圳湾实验室 特聘研究员

2019-2021  
哈佛大学 助理研究员

2014-2018  
哈佛大学 博士后

2010-2013
北京生命科学研究所 博士后

2005-2010
北京生命科学研究所/中国农业大学 博士

袁文课题组的研究将以自闭症和阿尔兹海默症得发病机制为主要方向，结合人类类脑器官的培养，高通量单细胞组学，CRISPR in vivo 大规模筛选技术，空间转录组学以及非人灵长类动物模型等多学科的综合手段研究这两种疾病的发病机制。综合应用表观遗传学和衰老领域得相关理论以及相应的实验手段，系统性阐释验证相关基因和信号通路导致神经疾病的机理。希望在未来的5年内，找到可以缓解自闭症以及阿尔兹海默症的相应小分子或蛋白，为治疗神经疾病提供新的靶点以及线索。

Wen Yuan; Sai Ma; Juliana R. Brown; Kwanho Kim; Vanessa Murek; Lucia Trastulla; Alexander Meissner; Simona Lodato; Ashwin S. Shetty; Joshua Z. Levin; Jason D. Buenrostro; Michael J. Zille r; Paola Arlotta ; Temporally divergent regulatory mechanisms govern neuronal diversification and maturation in the mouse and marmoset neocortex, Nature Neuroscience, 2022, 25: 1049-1058

Yuan, Wen; Wu, Tong; Fu, Hang; Dai, Chao; Wu, Hui; Liu, Nan; Li, Xiang; Xu, Mo; Zhang, Zh uqiang; Niu, Tianhui; Han, Zhifu; Chai, Jijie; Zhou, Xianghong Jasmine; Gao, Shaorong; Zhu, Bing ; Dense Chromatin Activates Polycomb Repressive Complex 2 to Regulate H3 Lysine 27 Methylation, SCIENCE, 2012, 6097(337): 971-975

Wen Yuan; Mo Xu; Chang Huang; Nan Liu; She Chen; Bing Zhu ; H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation, Journal of Biological Chemistry, 2011, 286(10): 7983-7989

Wen Yuan; Jingwei Xie; Chengzu Long; Hediye Erdjument-Bromage; Xiaojun Ding; Yong Zheng; Paul Tempst; She Chen; Bing Zhu; Danny Reinberg; Heterogeneous Nuclear Ribonucleoprotein L Is a Subunit of Human KMT3a/Set2 Complex Required for H3 Lys-36 Trimethylation Activityin Vivo, Journal of Biological Chemistry, 2009, 284(23): 15701-15707

Simona Lodato; Bradley J Molyneaux; Emanuela Zuccaro; Loyal A Goff; Hsu-Hsin Chen; Wen Yuan; Alyssa Meleski; Emi Takahashi; Shaun Mahony; John L Rinn; David K Gifford; Paola Arlotta ; Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons, Nature Neuroscience, 2014, 17(8): 1046-1054