Subordinate Research Institute
- Institute of Cancer Research
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The Institute of Cancer Research aims to create an excellent intellectual basis that enables scientists to work across boundaries for stimulating solutions to questions that challenge the cancer research community. The Institute will sharpen focuses in driving path-breaking discoveries in a way that serves the public good, and will foster collaborations with different international hospitals, pharma enterprises as well as scientific institutes across disciplines to seek achievements in discoveries not only from single-cell level but population-based cohort study. The Institute of Cancer Research aspires to lead global research in primarily 2 to 3 research areas regarding cancer biology and clinical trials. These efforts will join the Chinese strategic guidelines in facilitating cancer-related translational research and therapeutic innovation across and beyond the Guangdong-Hong Kong-Macao Greater Bay Area and will also ensure proactive alignment with the Healthy China initiative.
Research in the Institute of Cancer Research will be “clinical-oriented, translational-prioritized, technological-driven, theoretical-innovative”. Key areas will include:
- Novel technologies in cancer screening and early diagnosis
- New strategies and new drugs for cancer treatment
- Innovative theories in cancer-related molecular mutations and tumor microenvironment
- Innovative models, methodologies and applications of cancer BigData
- Institute for Metabolic and Cardiovascular Research
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The goal of the Institute of Metabolism and Cardiovascular Diseases Research is to develop successful approaches to the understanding, prevention and treatment of cardiovascular diseases, diabetes, and related metabolic diseases. The Institute is consisted of four interrelated research centers. They are:
1.Center for Clinical Metabolism
This research center aims to provide better understanding of human biology and deliver better treatments by studying new drugs, devices, diet, metabolism and other factors. Researchers at this center will investigate the mechanisms that govern metabolic health in patients including obesity and diabetes.
2.Centers for Integrative Metabolism
This center will develop successful approaches to the understanding, prevention and treatment of diabetes and related metabolic diseases in patients.
3.Center for Atherosclerosis and Aortopathy
This center strives to develop approaches to the understanding, prevention and treatment of vascular diseases.
4.Center for Heart Failure, Cardiomyopathy, and Cardiac Regeneration
This center will develop means to the understanding, prevention and treatment of heart failure and cardiac diseases.
- Institute of Neurological and Psychiatric Disorders
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The Institute of Neurological and Psychiatric Disorders aims to understand pathogenic mechanisms of brain disorders including autism, chronic pain, depression, sleep disorder, schizophrenia, and Alzheimer’s disease. The Institute encourages collaborations among scientists and clinicians with expertise in neuroscience, chemistry, engineering, computer science and medicine. With a better understanding of disease mechanisms, we hope to develop new ways to diagnose and treat neurological and psychiatric disease.
- Institute of Infectious Diseases
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The Institute of Infectious Diseases in Shenzhen Bay Laboratory was established in August 2020. It is an innovative research institution based on basic research, combining with public health and clinical research and committing to produce original diagnostic solution, vaccines and drugs. The institute will largely focus on the following areas: basic research on infectious diseases, research on anti-infective immunity, research and development of anti-infective drugs and vaccines, diagnosis of emerging infectious diseases, as well as epidemiological research of infectious diseases. It aims to establish a biosafety research system which is based on infectious diseases and public health research. Besides, the institute will put special attention on solving critical scientific questions in the field of infectious disease, and put effort into transforming the latest basic research results into application, so as to provide scientific and technological support for the prevention, diagnosis and treatment of major infectious diseases in China.
Key Research Development Areas:
1. The infection and immune mechanism of major infectious diseases
2. Etiology and genetic evolution of major infectious diseases
3. Development of vaccines and drugs for major infectious diseases
4. Detection technology for major infectious diseases.
- Institute of Systems and Physical Biology
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The Institute of Systems Biology of Shenzhen Bay Laboratory is dedicated to basic biomedical research, focusing on fundamental systems biology challenges by interdisciplinary collaborations broadly covering genomics and epigenetics, protein drug design, protein engineering and enzyme catalysis, signal transduction, bioinformatics and artificial intelligence, metabolic control, and photobiology. Systems biology integrates computational methods, e.g., molecular dynamics simulations and mathematical modeling, with biophysical and biochemical experiments, and different high-throughput omics techniques to investigate structure-function relations of living organisms at systems level, in order to unveil the underlying principles that are difficult to study in the traditional biological research. Some typical research areas are:
- Genomics and Epigenetics
The development and use of epigenetic sequencing technologies to study common cancers, infectious diseases, neuropsychological and metabolic disorders in Southern China. Network analysis and graph theory in the field of systems biology, analyzing data using mathematical models and artificial intelligence.
- Omics of Systems Biology
Priorities include proteomics, metabolomics, glycomics, transcriptomics etc. This involves developing advanced high-throughput testing methods and obtaining omics data related to specific diseases.
- Mathematical Biology
Analysis and use of big data from biological omics and health sciences to understand the fundamental processes of biological systems. This requires the development and building of mathematical and physical models, and the development of machine learning and artificial intelligence. Dynamical simulation of macromolecular assemblies at atomic resolution is essential for rational experimental design and verification.
Biological photochemistry - development of ultrafast laser technology to study how light-sensitive proteins induce energy and the charge transfer and chemical processes, as well as the resulting cell signaling mechanisms. Biosensing - development of non-invasive and high-sensitivity biosensing technologies. Medical imaging - linking genetic phenotypes with medical imaging. Priority lies in the research of new imaging technologies, and the development of ultrafast, super-resolution 3D and 4D imaging.
- Institute of Molecular Physiology
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The Institute of Molecular Physiology focuses research in two major areas - the molecular mechanism in important biological process and the development and application of advanced techniques in molecular biology. The former will primarily focus on the replication, repair, expression and regulation of genes and and other basic molecular biological events as such and associated mechanisms during the significant processes of genetic proliferation, aging and lesion.
The latter carries out research and application of molecular biotechs such as molecular evolution, gene editing, molecular marker for detection and gene therapy. Research will be both basic and applied, covering up four major aspects including gene repair and duplication, regulation of gene expression, molecular mechanisms of infectious diseases, techniques of molecular biology. Though these research and discovery, the Institute will effectively unite research from both basic and applied to facilitate the translation of research outcomes.
The Institute of Molecular Physiology plans to develop seven supporting research platforms:
- Molecular Imaging Facility
- Gene Library
- Animal Center
- High-throughput Screening Platform
- Genomics Center
- Proteomics Platform
- Transgenic Animal Center
- Institute of Chemical Biology
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The Institute of Chemical Biology strives to develop an academia-industry-market network for the translational community to advance discovery in health sciences and bio-pharmacy. It will steadfastly stimulate biotechs innovation and boost the development of the Greater Bay Area in accordance with the Healthy China strategic initiative. Together with Scripps Research, our global partner, ITM seeks to create a scientific platform in Shenzhen that will see and fully support the discovery, transformation and promotion of innovative drugs. Research in ITM will center around the following themes:
- Drug Screening Platform & Compound Library
We aim to build up a fully automatic ultra-high-flux screening system (uHTS) capable of lead compound sorting and compound management functions; construct unique and customized large-scale compound libraries with a total amount of around 1 million compounds; establish a Calibr-based ReFrame library and re-build a drug redevelopment compound library that contains over 15,000 compounds.
- Laboratory Platform Construction
Including: 1) In-vitro Biology Laboratory; 2)Medicinal Chemistry Laboratory; 3)Protein Therapy Laboratory; 4)Pharmacology Laboratory
- Institute for Cell Analysis
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The Institute for Cell Analysis (ICA) aims to establish a world-leading research institute for research on cell analysis. ICA will focus on developing the cutting-edge technologies for cell analysis, and is oriented by interests in fields ranging from fundamental biology to public health. ICA will foster technological innovations that lead to breakthrough in related fields, highlighting the following objectives:
1. Development of novel techniques for cell analysis that focuses on state-of-the-art methodologies for protein analysis
- Novel mass spectrometry imaging techniques
- Novel approaches to single-cell proteomics
- Novel techniques for protein interaction characterization
2.Development of high-throughput automated multi-omics techniques at single-cell resolution that focus on characterization, manipulation and procession of minute amount of cells
- Imaging of transcriptomes and proteomes at high spatial resolution, and integrative acquisition of multi-omics data
- Investigation on fundamental scientific and engineering problems of control and transportation of micro-scale fluid
- Automated processing of integrative multi-omics data, and their visualization
3. Establishment of a world-leading platform for research on cell analysis
- An innovative arsenal for multi-omics studies
- A supporting environment for multi-omics integration
- An open framework for collaboration
- Institute of Biomedical Engineering
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As a rising innovation hub in the Greater Bay Area of Guangdong-Hong Kong-Macao (GHM), the Institute of Biomedical Engineering (IBME) aims to convene a visionary and innovative group of scientists and engineers to create a world-class R&D environment. We are combining the Healthy China Initiative and the national strategy of developing Shenzhen City as a global leader in pharmaceutical technology and bioinformatics. To realize this goal, IBME will undertake a broad range of interdisciplinary and translational research that targets impactful and influential discoveries. In addition, as an aspiring institution, IBME will demonstrate firm commitment to developing a service facility of medical imaging and precision medicine. We are dedicated to harvest core technologies with local institutions and enterprises for regional economic growth.
Key Research Areas:
-Medical Imaging Science and Technology
Advanced medical imaging technologies in ultrahigh-field MRI, ultrawide-bore PET/CT, molecular probes for multimodal imaging and other methods of diagnosis and research of major diseases in brain disorders, cancer, cardiovascular diseases and metabolic disorders.
- Vision Science and Technology
Teenage myopia and blinding eye diseases in old adults are two major diseases that impact public health. We will develop quantitative methods and devices that help to diagnose and treat these diseases. Additional efforts will be made to promote active-health and to improve the management of chronic diseases based vision information. We will initiate advanced studies on ophthalmic theories as well as new techniques and tools based on multimodal imaging data and AI analysis.
- Smart Medical Devices and Technology
Research in this area will originate from new mechanisms and new approaches to tackle bottle-neck problems in the development of smart medical devices. In this effort, we aim to develop smart and adaptive devices that help to create novel approaches for clinical trials.
- Computational Medicine and Health Informatics
Research will be focused around medical big data and AI-aided frontier diagnostics in cardiovascular and cerebrovascular diseases, diabetes, cancer and other major life-threatening diseases.
- Institute of Biomedical Health Technology and Engineering
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The Institute of Biomedical Health Technology and Engineering is established to push forward global biomedical research and drive breakthroughs in original discovery of innovative drugs, new vaccines, health engineering and so forth with our distinctive intellectual strengths. Research in our Institute will be transdisciplinary, with top-notch scientists involved, we carry out our mission in terms of national strategic demands and strive to unblock bottlenecks in the development of health sciences. We aim to deliver research excellence by bringing together diverse translational resources from the domains of industry, academia, research and medical health, to foster highly competitive innovation capability that serves the greater good of the public, entrepreneurial prosperity and the global competitiveness of Shenzhen in the sector of medical health.
- Greater Bay Biomedical InnoCenter
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The Greater Bay Biomedical InnoCenter located in the Greater Bay Area is a cross-cooperative scientific research base in the Guangdong-Hong Kong-Macao region. We are recruiting outstanding scientists worldwide and sincerely inviting senior scholars in the life science field in the Greater Bay Area to conduct joint scientific research activities and academic exchanges. Our advantage is that full-time research scientists can engage part-time in scientific research and teach in universities in Hong Kong and Macau according to their different research fields. We aim to carry out major joint projects in multiple areas to solve scientific research problems that would otherwise be impossible to carry out by single research groups. Our approach is to adopt a variety of research methods such as [in the fields of] biochemistry, cell biology, molecular biology, biophysics, genetics, bioinformatics and imaging technology, etc., and carrying out basic research in the field of life science to obtain high-level original scientific research results. Our mission is to promote originality, breakthroughs, commitment to significant scientific discoveries, and world-leading technological innovations. We are dedicated to embracing the challenge to lead the scientific development of the Guangdong-Hong Kong-Macao Greater Bay Area to a whole new level.
- PKU-Princeton Research Center for Drug Development
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PKU-Princeton Research Center for Drug Development aims at creating a high-end R&D platform for biomedical research. The Center will focus on the research of innovative drugs, promoting academia-industry collaboration while accelerating the translation of new core technology. It will serve as an important role for industrial contribution and the nurturing of spin-off biotech pharmas, in pursuit of creating an robust and innovative ecosystem specially in the bio-pharmaceutical sector. The Center carries out the mission of adapting new models for global collaboration to incrementally strengthen its capacity in delivering sci-tech innovation and translation, and to realize the potential of becoming an sci-tech innovation hub that committed to biomedical discovery in the Guangdong-Hong Kong-Macao Greater Bay Area. Research interests are as follows:
We plan to establish two R&D platforms for discovery in new drugs at the initial stage:
1.Biological Activity Research Platform: this platform aims to study the structure and function of the targeted protein and related target genes through the specific interaction between small molecular compound probes and target protein, while at the same time identifying and confirming the targets and the pilot compounds of new drugs.
2.Pharmaceutical Chemistry Research Platform: this platform will comprise 2 sub-platforms, namely the small molecular pharmaceutical chemistry platform and the polypeptide research platform.
We also plan to set up a Computational Chemistry Platform to develop efficient conformational search algorithms based on quantum mechanical calculations; study the effects of chemical modification on the conformation and binding capacity of polypeptides and proteins; establish a computer-aided drug R&D system; develop efficient methods to accurately estimate the impact of different improvements in lead compounds on affinity.
- BayRay Innovation Center
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BayRay started operations in May 2019 as a drug discovery technology and product-focused innovation center. BayRay aims to bridge the innovation gap between academia and industry in the Chinese biomedical industry by partnering with world class academic centers and companies to develop cutting edge drug discovery technologies around early stage drug development projects. We focus on novelty and originality of early stage discovery science out of academia with the goal to create valuable intellectual property and core technologies that will become game changers in their respective fields. At present, all our projects involve small molecule drug discovery, one of our core strengths. In a second stage we will also add projects and technology platforms involving biologic drugs.
BayRay has defined the following criteria for selection of novel projects: (1) Unmet medical (or technological) need, (2) early stage project with high innovation potential, (3) qualified project team and feasibility of proof of concept studies at BayRay, and (4) intellectual property creation and market potential.
- Pingshan Translational Medicine Center
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Pingshan Translational Medicine Center（PTMC）aims to take best practices at integrating the biomedical resources from Shenzhen, the Greater Bay Area and the rest of the world, to deliver ongoing inputs and create top-notch research platform for the biomedical research community. The Center will facilitate a broad range of large-scale research initiatives which cannot be single-handedly carried out by universities or enterprises, and will provide support to build a complete ecosystem for thriving biotechs and to drive the sizable development of bio high-tech industry.
The PTMC will work to launch core R&D platforms for new drug discovery, including:
- Chemical biology module, small molecular medicinal&chemical module, and polypeptide protein medicinal chemistry module;
- New mechanism of drug, new target validation and drug discovery;
- Disease highly-relevant intracellular polypetide stablized regulator;
- Drug molecule-target interaction based on chemical biology, computing chemistry and AI.
Also, we will absorb four initial-stage projects for the planned technology transfer platform:
- Cycling dependent kinase 9 inhibitor;
- New-generation inhibitor targeting anti-drug resistant anaplastic lymphoma kinase Type-I 1/2;
- Targeted drugs for drug-resistance relapse estrogen receptor-positive breast cancer;
- Specific target drugs for Class I histone deacetylase.