骐骥一跃,不能十步
驽马十驾,功在不舍
张洋
Yang ZHANG
分子生理学研究所
Timeline
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2022 至今
深圳湾实验室 特聘研究员
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2020 – 2022
杜克大学生物化学系 资深博士后
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2015 – 2020
杜克大学生物化学系 博士后
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2014 – 2015
中科院深圳先进技术研究院 助理研究员
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2009– 2014
华中科技大学 生物医学工程专业 博士
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2005 – 2009
华中科技大学 生物医学工程专业 学士
研究领域
离子、磷脂的跨膜转运。课题组运用多种分子学方法,结合电生理、光学成像等技术手段,研究离子通道与磷脂翻转酶在生理与病理中的功能,为治疗发育异常、凝血功能障碍、病毒感染等相关疾病提供治疗方法。
成果
1. 理解TMEM16钙调离子通道与钙调磷脂翻转酶的生理功能
a) 发现新型钙调氯离子通道在运动学习中的功能; b) 发现调控细胞融合的新机制; c) 揭示生理与病理条件下钙信号的调控。
2. 发展用于理解离子、磷脂转运体的生理、病理功能的新技术、新方法
a) 发展用于神经-胶质-血管在体三维可视化的光学新方法;b) 发明用于模式动物脑功能的无损监测技术
发表论文18篇,其中以第一作者在Neuron, Science Advances, eLife, IEEE Transactions on Medical imaging 等期刊发表论文8篇,在Cancer Discovery, PNAS, Nature Communications, Journal of Biological Chemistry 等期刊合作发表论文10篇。授权发明专利四项。
荣誉
2022 Gordon Research Conference Best Poster Presentation Award
2022 Duke Biochemistry Retreat Poster Award
2019 Layton Holladay Memorial Fund基金会奖
2017 Burroughs Wellcome Fund合作研究奖
2016 Joy Cappel 青年科学家奖
代表论文
1. Y. Zhang, P. Liang, L. Yang K. Shan, L. Feng, Y. Chen, W. Liedtke, C. B. Coyne, H. Yang, Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion. eLife 11: e78840 (2022)
2. Y. Zhang, T. Le, R. Grabau, Z. Mohseni, H. Kim, D. R. Natale, L. Feng, H. Pan, H. Yang, TMEM16F phospholipid scramblase mediates trophoblast fusion and placental development. Science Advances 6, eaba0310, 2020
3. Y. Zhang, Z. Zhang, S. Xiao, J. Tien, S. Le, T. Le, L. Y. Jan, H. Yang, Inferior olivary TMEM16B mediates cerebellar motor learning, Neuron, 95:1103–1111, 2017
4. X. Yang#, Y. Zhang#, K. Zhao, Y. Zhao, Y. Liu, H. Gong, Q. Luo, and D. Zhu, Skull Optical Clearing Solution for Enhancing Ultrasonic and Photoacoustic Imaging., IEEE Transactions on Medical imaging, 35(8):1903-6, 2016
5. C. Liao, Y. Zhang, C. Fan, L. E. Herring, J. Liu, J. W. Locasale, G. Zurlo, L. Hu, J. M. Simon, T. S. Ptacek, O. Pugovics, E. Loza, H. Yang, C. M. Perou, and Q. Zhang, Identification of BBOX1 as a therapeutic target in triple-negative breast cancer, Cancer Discovery 10(11): 1706-1721, 2020
6. P. Dong, Y. Zhang, M. A. Mikati, J. Cui, H. Yang, Neuronal mechanism of a BK channelopathy in absence epilepsy and dyskinesia. PNAS 119 (12) e2200140119, 2022
7. Y. Zhang, H. Yang, A simple and robust fluorescent labeling method to quantify trophoblast fusion, Placenta, 77:16-18, 2019
8. Y. Zhang, C. Zhang, X. Zhong, D. Zhu,Quantitative evaluation of SOCS-induced optical clearing efficiency of skull, Quantitative Imaging in Medicine and Surgery, 5(1), 136-142, 2015
9. Y. Zhang, Y. Chen, Y. Yu, X. Xue, V. V. Tuchin, and D. Zhu, Visible and near-infrared spectroscopy for distinguishing malignant tumor tissue from benign tumor and normal breast tissues in vitro, Journal of Biomedical Optics 18(7), 077003, 2013
10. J. Wang#, Y. Zhang#, T. Xu, Q. Luo, and D. Zhu, An innovative transparent cranial window based on skull optical clearing, Laser Physics Letters 9(6), 469-473, 2012