研究方向

1. 肌肉发育与损伤修复过程中的信号传导通路。

2. 肌肉干细胞增殖分化过程中关键基因的功能及其分子机制研究。

成果

已在Cell Stem Cell，PNAS，Cell Research，EMBO Journal 等期刊发表论文70 余篇。主持国家自然科学基金委员会与香港研究资助局联合科研基金项目，N_HKUST621/08 (2009-2011)，N_HKUST633/18 (2019-2022)，资助金额总计约160 万港币。 主持香港研究资助局基金项目，从2000- 2019 年共计资助17 次，资助金额总计逾2000 万港币。

荣誉

• Overseas Distinguished Young Scholar fund (B), (2004-2007), National Natural Science Foundation of China (NSFC) 

• Long-term fellowship, Human Frontier Science Program (International Human Frontier Science Program Organization, 1996-1998) 

代表论文

1. Lifang Han, Gang Wang, Shaopu Zhou, Chenghao Situ, Zhiming He, Yuying Li, Yudan Qiu, Yu Huang, Aimin Xu, Michael Tim Yun Ong, Huating Wang, Jianfa Zhang, and Zhenguo Wu (2022). Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine. Cell Reports. 39: 110884.

2. Shaopu Zhou, Lifang Han, Mingxi Weng, Han Zhu, Youshan Heng, Gang Wang, Zeyu Shen, Xianwei Chen, Xinrong Fu, Mingjie Zhang, and Zhenguo Wu (2021). Paxbp1 controls a key checkpoint for cell growth and survival during early activation of quiescent muscle satellite cells. PNAS. 118: e2021093118.

3. Gang Wang, Han Zhu, Chenghao Situ, Lifang Han, Youqian Yu, Tom HT Cheung, Kai Liu, and Zhenguo Wu (2018). p110α of PI3K is necessary and sufficient for quiescence exit in adult muscle satellite cells. EMBO Jounral. 37: e98239.

4. Yitai An, Gang Wang, Yarui Diao, Yanyang Long, Xinrong Fu, Mingxi Weng, Leina Zhou, Kun Sun, Tom HT Cheung, Nancy Y Ip, Hao Sun, Huating Wang, and Zhenguo Wu (2017). A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes. Development Cell. 41:382-91. 

5. Han Zhu, Fang Xiao, Gang Wang, Xiuqing Wei, Lei Jiang, Yan Chen, Lin Zhu, Haixia Wang, Yaui Diao, Huating Wang, Nancy Y Ip, Tom HT Cheung, and Zhenguo Wu (2016). STAT3 Regulates Self-renewal of Adult Muscle Satellite Cells During Injury-induced Muscle Regeneration. Cell Reports. 16: 2102-15.