科学研究

科学研究

科学研究

王超

创新之路或孤独昏暗, 但终为来者点亮光明!

王超

Chao WANG

系统与物理生物学研究所

特聘研究员

chaowang@szbl.ac.cn

Timeline

  • 2023 至今

    深圳湾实验         特聘研究员

  • 2013-2023

    美国斯克里普斯研究所         博士后、职员科学家、高级职员科学家

  • 2007-2012

    中国科学院生物物理研究所         生物化学与分子生物学博士

  • 2003-2007

    厦门大学生物科学         学士











研究领域


课题组主要研究方向为细胞内蛋白质稳态系统及精准药物智能设计。课题组以人群基因组及表型组为基础,利用多学科技术,包括计算生物学、分子生物学、细胞生物学、生物化学、生物物理学及多组学等手段,来揭示细胞、组织及个体在人群进化、环境应激及疾病衰老中调控蛋白质折叠及功能的分子机制,并进行精准药物的设计和研发。涉及疾病包括与蛋白质错误折叠相关的遗传病、慢性阻塞性肺病、癌症及神经退行性疾病等。






成果


王超博士长期致力于蛋白质体内折叠和稳态的研究,近年做出了多项原创成果:1) 研发了新的机器学习算法来揭示人群中蛋白突变体在细胞中各异的致病机制及对不同药物的响应机制以发现新的精准药物靶点(Cell Reports, 2018; Structure, 2022)。2) 阐明了表观遗传及分子伴侣影响蛋白质稳态的新机制以精准治疗神经退行性疾病(Nat. Commun., 2019; Hum. Mol. Genet., 2020)。3) 利用机器学习及激活未折叠蛋白反应的小分子发现治疗复杂遗传病的新途径(Cell Chemical Biology, 2023)。王超博士以第一作者 (含共同) 在国际期刊发表文章11篇。多项成果被Cell Chemical Biology、Trends in Genetics、Faculty Opinions 等专门撰文评述推荐。以第一发明人申请国际/美国专利一项并主导多个疾病的小分子药物开发。现任国际期刊Journal of Biological Chemistry 青年审稿委员会成员。受邀多次在国际学术会议作报告,并曾获中德林岛诺贝尔奖得主大会基金会、吴瑞奖学金、美国Alpha-1基金会及Cystic Fibrosis科研基金会等资助。

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荣誉


•  2016-2019 美国Cystic Fibrosis基金会博士后奖学金。

•  2014-2015 美国Alpha-1基金会博士后奖学金。

•  2012 吴瑞奖

•  2012 北京优秀毕业生

•  2012 朱李月华中国科学院优秀博士生奖学金

•  2011 获中德中心资助参加第61届林岛诺贝尔奖获得者大会






媒体报道


1. Pharmacological management of disease by overcoming structural adversity: Cell Chemical Biology

2. Computational Approach Demonstrates Why Cystic Fibrosis Drugs Fall Short

3. Drilling for rare disease therapeutics

4. Drilling for Insight: Forecasting Phenotype from Genotype

5. Want to know which mutations are really risky? New Scripps Research method may help






招聘信息


包括实验方向及计算方向的博士后,联合培养博士生及研究助理

详情链接:https://new.qq.com/rain/a/20230321A00SE600  






代表论文


1. Sun, S.*, Wang, C.*, Zhao, P., Kline, G., Grandjean, J., Jiang, X., Labaudiniere, R., Wiseman, R.L., Kelly, J.W., and Balch, W.E. (2023) Capturing the Conversion of the Pathogenic Alpha-1-Antitrypsin Fold by ATF6 Enhanced Proteostasis. (*contributed equally). Cell Chemical Biology 30(1): 22-42,  https://doi.org/10.1016/j.chembiol.2022.12.004.

· Highlighted by preview in Cell Chemical Biology. https://doi.org/10.1016/j.chembiol.2022.12.008.

2.  Wang, C.*, Angles, F.*, & Balch, W.E. (2022) Triangulating variation in the population to define mechanisms for precision management of genetic disease. Structure. 30(8): 1190-1207. (*contributed equally). Link: https://doi.org/10.1016/j.str.2022.05.011.

· Highlighted in Genetic Engineering & Biotechnology News, Cystic Fibrosis News Today, ScienceDaily, Scripps News&Views etc. 

3. Wang, C.*, Zhao, P.*, Sun, S.*, Teckman, J., & Balch, W.E. (2020) Leveraging Population Genomics for Individualized Correction of the Hallmarks of Alpha-1-Antitrypsin Deficiency (AATD). Chronic Obstr Pulm Dis. 7(3): 224-246. (*contributed equally). Link: https://doi.org/10.15326/jcopdf.7.3.2019.0167.

4. Wang, C. *, Scott, S.M.*, Sun, S., Zhao, P., Hutt, D.M., Shao, H., Gestwicki, J.E., & Balch, W.E.  (2020) : Individualized Management of Genetic Diversity in Niemann-Pick C1 through Modulation of the Hsp70 Chaperone System. Hum. Mol. Genet. 29(1):1-19. (*contributed equally). Link: https://doi.org/10.1093/hmg/ddz215.

5. Wang, C., Scott, S.M., Subramanian, K., Loguercio, S., Zhao, P., Hutt, D.M., Farhat, N.Y., Porter, F.D., & Balch W.E. (2019) Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process. Nat. Commun. 10(1):5052. Link: https://doi.org/10.1038/s41467-019-12969-x.

6. Wang, C., Balch, W.E. (2018) Bridging Genomics to Phenomics at Atomic Resolution Using Variation Spatial Profiling. Cell Reports. 24(8): 2013-2028. Link: https://doi.org/10.1016/j.celrep.2018.07.059.

· Featured as Cover story. · Featured in spotlight section of Trends in Genetics. 34(11):821-822.

· Recommended by Faculty Opinions.

7. Wang, C., Bouchecareilh, M. & Balch, W. E. (2017) Measuring the Effect of Histone Deacetylase Inhibitors (HDACi) on the Secretion and Activity of Alpha1-Antitrypsin. Methods in Molecular Biology. 1639:185-193. Link: https://doi.org/10.1007/978-1-4939-7163-3_18.

8. Wang, C. & Balch, W. E. (2016) Managing the Adaptive Proteostatic Landscape: Restoring Resilience in Alpha-1 Antitrypsin Deficiency. in Alpha-1 Antitrypsin: Role in Health and Disease (Wanner, A. & Sandhaus, R. A., eds). Respir. Med. Link: https://doi.org/10.1007/978-3-319-23449-6_4.

9. Wang, C.*, Li, W.*, Ren, J., Fang, J., Ke, H., Gong, W., Feng, W. & Wang, C. C. (2013) Structural insights into the redox-regulated dynamic conformations of human protein disulfide isomerase. Antioxid Redox Signal. 19, 36-45. (*contributed equally). Link: https://doi.org/10.1089/ars.2012.4630.

10. Wang, C.*, Yu, J. *, Huo, L., Wang, L., Feng, W. & Wang, C. C. (2012) Human protein-disulfide isomerase is a redox-regulated chaperone activated by oxidation of domain a'. J Biol Chem. 287, 1139-49. (*contributed equally). Link: https://doi.org/10.1074/jbc.M111.303149.

11. Wang, C.*, Chen, S.*, Wang, X., Wang, L., Wallis, A. K., Freedman, R. B. & Wang, C. C. (2010) Plasticity of human protein disulfide isomerase: evidence for mobility around the X-linker region and its functional significance, J Biol Chem. 285, 26788-97. (*contributed equally). Link: https://doi.org/10.1074/jbc.M110.107839