研究领域

1. 病人特异性诱导多能干细胞在心血管疾病精准医学及再生领域的应用

2. 非心肌细胞在心血管疾病发生发展中的作用机制

3. 基于表型的高通量筛选的研究

成果

张喆博士专注于心血管领域基础与转化研究，利用人诱导多能干细胞（hiPSCs）和基因编辑技术围绕心血管领域中挑战性难题开展工作。首次构建双色荧光心脏谱系示踪工具并分离人源心脏谱系，发现细胞表面蛋白CORIN及进行精准药物检测。该示踪工具已提供给多个国际科研机构。首次利用病人特异性hiPSCs 验证不确定意义变体致病性，为hiPSCs应用于精准医学奠定坚实基础。以第一或共同第一作者在Cell Stem Cell 和 Circulation等顶级期刊发表文章7篇，共计21篇。荣获美国心脏协会Mentorship Program Award、国际心脏研究会欧洲分会Best Poster Prize、日本科学促进会HOPE Fellow和美国TRDRP博士后基金等。

代表性图片

人诱导多能干细胞衍生心肌细胞

荣誉

• 2021 基金委国家重大人才工程计划（青年）

• 2019 American Heart Association (AHA) Basic Cardiovascular Sciences (BCVS) Early Career Mentorship Program Award

• 2018 AHA BCVS Scientific Sessions New Investigator Travel Award

• 2017-2019 Tobacco-Related Disease Research Program (TRDRP) Postdoctoral Fellowship

• 2015 Japan Society for the Promotion of Science (JSPS) HOPE Fellow

• 2015 International Society for Heart Research (ISHR)-European Section (ES) Best Poster Prize

• 2015 ISHR-ES Travel Award

• 2015 Maurice and Phyllis Paykel Trust Travel Award

• 2015 Brooker United Travel Doctoral Travel Scholarship

• 2014 Nominated delegate by Royal Society of New Zealand to attend the 7^th HOPE meeting with Nobel Laureates in Japan

• 2014 Exemplary Participant Award at Gordon Research Seminar

• 2013 Claude McCarthy Fellowship

• 2013 Elman Poole Scholarship

• 2012-2015 University of Otago Doctoral Scholarship

媒体报道

Otago Daily Times: Trio off to Japan meeting

招聘信息

1. 张喆课题组招聘详情

代表论文

1. Zhang JZ*, Belbachir N*, Zhang T*, Liu Y, Shrestha R, Wu JC. (2021). Effect of Cryopreservation on Human iPSC-Derived Cardiomyocytes for Assessing Drug Safety Response Profiles. Stem Cell Reports, 16(1):168-181. (* Co-first author)

2. Zhang JZ, Termglinchan V, Shao NY, Itzhaki I, Liu C, Ma N, Tian L, Wang VY, Chang ACY, Guo H, Kitani T, Wu H, Lam CK, Kodo K, Sayed N, Blau HM, Wu JC. (2019). A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles. Cell Stem Cell, 24(5): 802-811.e5.

3. Ma N*, Zhang JZ*, Itzhaki I*, Zhang SL, Chen H, Haddad F, Kitani T, Wilson KD, Tian L, Shrestha R, Wu H, Lam CK, Sayed N, Wu JC. (2018). Determining the Pathogenicity of a Genomic Variant of Uncertain Significance Using CRISPR/Cas9 and Human Induced Pluripotent Stem Cells. Circulation, 138(23):2666-2681. (* Co-first author)

4. Zhang JZ, Guo HC, Wu JC. (2018). Applications of genetically engineered human pluripotent stem cell reporters in cardiac stem cell biology. Current Opinion in Biotechnology, 52:66-73.

5. Zhang JZ, Waddell HM, Wu E, Dholakia J, Okolo CA, McLay JC, Jones PP. (2016). FKBPs facilitate the termination of spontaneous Ca2+ release in wild-type RyR2 but not CPVT mutant RyR2. Biochemical Journal, 473(14), 2049-60.