Yamamoto Nobuhiko-深圳湾实验室

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首页科学研究科研团队 Yamamoto Nobuhiko

Yamamoto, Nobuhiko/

所/中心

神经疾病研究所

电子邮箱

nobuhiko@szbl.ac.cn

研究方向

细胞生物学、分子生物学、神经科学

Timeline

研究领域

研究成果

荣誉奖励

媒体报道

招聘信息

代表论文

Timeline

2022 - Present

Shenzhen Bay Laboratory

Senior Principal Investigator

2002 - 2022

Grad School of Frontier Biosciences, Osaka University

Professor

1994 - 2002

Grad School of Engineering Science, Osaka University

Associate Professor

1986 - 1994

Kyoto Pref University Medicine

Assistant Prof and Lecture

1982 - 1986

Department of Biophysical Engineering, Faculty of Engineering Science

Osaka University Awarded the degree of PhD in neurobiology for a thesis entitled "Studies of a neurite outgrowth-promoting factor from heart-cell conditioned medium"

1980 - 1982

Awarded Master's degree in neurobiology for a study of neuronal circuits in pupil reflex

Master

1976 - 1980

Faculty of Engineering Science, Osaka University

Awarded Bachelor's degree

研究领域

Our lab investigates the regulatory mechanisms of neuronal activity-dependent gene expression, which are involved in neuronal circuit formation and remodeling, from the physiological, pathological and evolutional points of view, usingin vitroandin vivoimaging, gene expression analyses, and cellular biological techniques such as our original slice culture method.

研究成果

Dr Yamamoto obtained a PhD in Nakaakira Tsukahara lab of Osaka University by studying neurite outgrowth-promoting factor from heart cell conditioned medium. He then joined Keisuke Toyama lab in Kyoto Prefectural University of Medicine. During the period, he pioneered a new organotypic culture method (interface type) with semipermeable membranes (Yamamoto et al.,Science, 1989) and demonstrated that specific neuronal connections are establishedin vitro(Yamamoto et al.,Neuron, 1992). In 1994 he returned to Osaka University as associate professor, and in 2002 joined Graduate School of Frontier Biosciences in Osaka University as a full professor.

His lab has been mainly interested in cellular and molecular mechanisms of neuronal wiring. They have shown the mechanisms underlying formation of lamina-specific cortical connections using the in vitro approaches (Yamamoto et al.,J Neurosci, 1997;J Neurosci, 2000). They have also demonstrated the role of neuronal activity in cortical circuit formation (Uesaka et al,J Neurosci, 2005, 2007; Yamada et al.,PNAS, 2010) and the molecular mechanisms underlying activity-dependent axon branching by using various techniques of cellular biology, electrophysiology and molecular biology (Ohnami et al.,J Neurosci, 2008; Hayano et al.,PNAS, 2014, Sasaki et al.,Cereb Cortex, 2020).

More recently, they have shown the influence of physiological stimulation on activity-dependent gene expression (Miyasaka and Yamamoto,Frontier Neurosci, 2021), the activity-dependent dynamics of a transcription factor in cortical neurons (Kitagawa et al.,J Neurosci, 2017), the molecular mechanisms of lesion-induced axonal sprouting (Chang et al.,J Neurosci, 2022), and the role of afferent-specific molecules in neocortical cytoarchitecture (Sato et al.,eLife, 2022).

荣誉奖励

媒体报道

招聘信息

代表论文

1.Yamamoto N, Kurotani T, Toyama K (1989) Neural connections between the lateral geniculate nucleus and visual cortex in vitro.Science245:192-194

2.Yamamoto N, Yamada K, Kurotani T, Toyama K (1992) Laminar specificity of extrinsic cortical connections studied in coculture preparations.Neuron9:217-228.

3.Yamamoto N, Higashi S, Toyama K (1997) Stop and Branch behaviors of geniculocortical axons: A time-lapse study in organotypic cocultures.J Neurosci17:3653-3663.

4.Yamamoto N, Inui K, Matsuyama Y, Harada A, Hanamura K, Murakami F Ruthazer ES, Rutishauser U, Seki T (2000) Inhibitory mechanism by polysialic acid for lamina-specific branch formation of thalamocortical axons.J Neurosci20:9145-9151.

5. Uesaka N, Hirai S, Maruyama T, Ruthazer E,Yamamoto N(2005) Activity-dependence of cortical axon branch formation: A morphological and electrophysiological study using organotypic slice cultures.J Neurosci25:1-9.

6. Yamada A, Uesaka N, Hayano Y, Tabata, T, Kano M,Yamamoto N(2010) Role of pre- and postsynaptic activity in thalamocortical axon branching.Proc Natl Acad Sci U S A107: 7562-7567.

7. Hayano Y, Sasaki K, Ohmura N, Takemoto M, Maeda Y, Yamashita T, Hata Y, Kitada K,Yamamoto N(2014) Netrin-4 regulates thalamocortical axon branching in an activity-dependent fashion.Proc Natl Acad Sci U S A111:15226-15331.

8. Kitagawa H, Sugo N, Morimatsu M, Arai Y, Yanagida T,Yamamoto N(2017) Activity-dependent dynamics of the transcription factor CREB in cortical neurons revealed by single-molecule imaging.J Neurosci37:1-10.

9. Chang L, Masada M, Kojima M,Yamamoto N(2022) Involvement of denervated midbrain-derived factors in the formation of ectopic cortico-mesencephalic project-tion after hemispherectomy.J Neurosci42: 749-761.

10. Sato H, Hatakeyama J, Iwasato T, Arai K,Yamamoto N, Shimamura K (2022) Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of VGF.eLife11: e67549.

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