特聘研究员
博士后
博士
硕士
学士
主要研究方向为开发可靶向核酸分子的小分子化合物,构建新型核酸药物递送系统,糖分子识别及功能性多肽开发等。我们的研究方法涉及功能性有机小分子合成, 多肽合成,分子识别研究及细胞生物学验证等。
研究期间以多肽骨架为基础,通过化学修饰的手段,开发了多种高效安全的核酸药物递送载体, 构建了高效的环状二核苷酸人工受体及糖分子识别受体等,目前欧洲专利申请一项。
1.M. Li, R. Puschmann, A, Herdlitschka, D. Fiedler, H. Wennemers;Delivery of myo-inositol hexakisphosphate to the cell nucleus with a proline-based cell penetrating peptide;Angew. Chem. Int. Ed.2020, 59,15586(hot paper).
2.M. Li,M. R. Stojković, M. Ehlers, E. Zellermann, I. Piantanida, C. Schmuck; Use of an Octapeptide–Guanidiniocarbonylpyrrole Conjugate for the Formation of a Supramolecular β‐Helix that Self‐Assembles into pH‐Responsive Fibers;Angew. Chem. Int. Ed.2016, 55,13015.
3.M. Li, M. Ehlers, S. Schlesiger, E. Zellermann, S. K. Knauer, C. Schmuck; Incorporation of a Non‐Natural Arginine Analogue into a Cyclic Peptide Leads to Formation of Positively Charged Nanofibers Capable of Gene Transfection;Angew. Chem. Int. Ed.2016,55, 598.
4.M. Li,S. Schlesiger, S. K. Knauer, C. Schmuck;A Tailor‐Made Specific Anion‐Binding Motif in the Side Chain Transforms a Tetrapeptide into an Efficient Vector for Gene Delivery;Angew. Chem. Int. Ed.2015,54, 2984.
5.M. Li,S. Schlesiger, S. K. Knauer, C. Schmuck;A dipeptide with enhanced anion binding affinity enables cell uptake and protein delivery;Org. Biomol. Chem.2018,16, 2312.
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