研究方向

表观遗传学，基因组学，3D基因组学，转录调控与疾病，有丝分裂，衰老

成果

· 建立了早老症(HGPS)病人血管平滑肌细胞的体外诱导分化系统。

· 首次阐明了早老症病人血管平滑肌细胞死亡的分子机制，为早衰症治疗提供了新思路。

· 首次阐明了动物细胞染色质在有丝分裂之后子细胞当中的重塑过程，解析了染色质结构蛋白CTCF以及cohesin环复合体在有丝分裂后与染色质重新结合的动力学特征。为环挤压模型（loop extrusion model）在有丝分裂后染色质三维结构的重塑的调控作用提供了有力证据。

· 阐释了有丝分裂后染色质结构重塑与基因转录重启之间的关系。

· 阐明了染色质结构蛋白CTCF在有丝分裂后染色质结构重塑中的作用

成果发表论文十余篇，并以第一作者身份在Nature, PNAS, Aging Cell 等杂志发表文章。并以共同作者身份在Nature Genetics, Genome Research, Cell Reports, Scientific Reports 等杂志发表文章。 

有丝分裂后A/B蛋白质区域（分段）重塑过程

荣誉

• 2017 Charles A. Caramello Distinguished Dissertation Award, University of Maryland College Park

• 2014 MOCB Travel Award, University of Maryland College Park

• 2014 BISI Merit Student Award, University of Maryland College Park

• 2013 Best Poster Presentation Award. University of Maryland, School of Medicine

• 2011 Dean' s Fellowship, University of Maryland College Park

• 2011 Best Thesis Award, Tongji University

• 2010 China National Scholarship, Ministry of Education, China

• 2009 First Class Scholarship, Tongji University

• 2009 Shanghai Scholarship, Shanghai Education Commission, China 

招聘信息

博士后

代表论文

1. Zhang, H., Emerson, D. J., Gilgenast, T. G., Titus, K. R., Lan, Y., Huang, P., ... Blobel, G. A. (2019). Chromatin Structure Dynamics During the Mitosis-to-G1 Phase Transition. Nature, 576(7785), 158-162. | DOI:10.1038/s41586-019-1778-y

2. Zhang H and Cao K (2016). Mechanisms of Genome Instability in Hutchinson-Gilford Progeria. Frontiers in Biology, DOI 10.1007/s11515-016-1435-x

3. Zhang H, Sun L, Wang K, Wu D, Trappio M, Witting C and Cao K (2016). Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome. Plos ONE, 11(12) e0167454. doi: 10.1371/journal. pone.0167454. PMID: 27907109

4. Zhang H, Xiong Z and Cao K (2014). Mechanisms Controlling the Smooth Muscle Cell Death in Progeria via Down-Regulation of poly(ADP-ribose) Polymerase 1. PNAS, 111(2) 2261-2270.

5. Zhang H, Keickhaefer JE and Cao K. (2013) Mouse Models of Laminopathies. Aging Cell, 12(1) 2-10.