Study of molecular mechanisms responsible for mechanotransduction in living cells.Understanding the role of mechanical and topological constraints in regulation of DNA-protein interactions and chromatin organization in living cells.Exploration of molecular mechanisms underlying mechanochemical coupling in cytoskeletal motor proteins, and their role in regulation of intracellular transportation.Development and application of single-molecule force-spectroscopy methods for investigation of the above questions.

I firmly believe that to be successful in drug discovery one must utilize cutting edge technologies, explore the full range of drug modalities and attempt to drug the most challenging targets. I am interested in pursuing targets from all therapeutic areas especially oncology and infectious disease.

The Tan lab focuses on drugging cell fate, where advanced chemical biology methods are developed and applied to identify natural product and synthetic chemical probes targeting a class of oncogenes called lineage transcription factors.

Our lab investigates the regulatory mechanisms of neuronal activity-dependent gene expression, which are involved in neuronal circuit formation and remodeling, from the physiological, pathological and evolutional points of view, using in vitro and in vivo imaging, gene expression analyses, and cellular biological techniques such as our original slice culture method.

The overarching aim of his laboratory is to characterize the biology of, and develop methods of inhibition to novel and clinically relevant proteins involved in the pathophysiology of breast and other functionally related cancers. They are focused to develop proof of principle inhibitory strategies to demonstrate the potential utility of these targets in oncology and generate novel therapeutic agents for eventual clinical use. Hence, evaluation of individual molecules for their potential therapeutic application and commercial exploitation also forms an important component of the work.

The Goh lab studies how RNA modifications (epitranscriptome) regulate gene expression and cellular processes by developing new technologies to sequence RNA modifications and functionally characterizing novel epitranscriptomic factors that interact with and metabolize RNA modifications. Defects in epitranscriptomic regulation cause a variety of diseases and determining the mechanistic basis that underlie these defects will be crucial for developing effective epitranscriptomic-based therapeutic strategies.

课题组致力于化学和生物医学交叉研究，通过开发新方法和新技术来解决生命科学领域的重要难题，为疾病诊断和治疗提供新工具和新思路。课题组具备化学生物学、化学合成、药物开发、基因编辑、基因密码子扩展技术等专长，专注于蛋白质活性调控的研究，并应用于癌症等疾病的诊断和治疗（包含小分子药物、生物制剂、基因疗法和细胞疗法）以及传染病的预防。

实验室长期研究目标为探索免疫代谢调控的分子机理。主要探讨机体内病原微生物（细菌和病毒）的致病机理；探讨天然免疫系统、细胞自主免疫（Cell-Autonomous Immunity）防御病原微生物的分子机理，尤其是免疫代谢产物在其中的重要作用。1. 病原微生物的致病机理。2. 机体抵抗病原微生物感染的分子机理。3. 新抗菌代谢物的筛选和鉴定。

我们将尝试向抗体和多肽中引入“化学活性”的非天然氨基酸，一方面，改善潜在药物分子的生物利用度、半衰期和安全性等成药性问题；另一方面，制备其衍生物，包括但不限于：招募并激活免疫细胞的多特异性抗体，特异性释放毒素分子的抗体毒素偶联物，以及特异降解肿瘤相关抗原的降解嵌合体等。

主要研究兴趣是理解宿主和微生物之间的共同演化，提出抗微生物感染的免疫治疗新策略。（1）探索微生物的免疫逃逸机制；（2）针对免疫逃逸机制筛选和优化抗原表位和单抗疗法；（3）探索宿主影响抗体疗法的作用机理，开发适合于不同人群的疫苗和单抗。