Humidity response in Drosophila olfactory sensory neurons requires the mechanosensitive channel TMEM63

Thus, our results reveal a role of Tmem63 in hygrosensation and support the strategy to detect humidity by transforming it into a mechanical stimulus,...

A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness

Given that RELMα can be specifically induced by a vitamin A derivative, the dietary administration of isotretinoin to flavivirus-infected animals inte...

Neuroligin-3 confines AMPA receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses

Microfluidic Platform for Time-Resolved Characterization of Protein Higher-Order Structures and Dynamics Using Top-Down Mass Spectrometry

This strategy may benefit elaborate structural analysis of biomacromolecules and inspire method development using the microchip-MS approach....

Lipases secreted by a gut bacterium inhibit arbovirus transmission in mosquitoes

The anti-arboviral and entomopathogenic properties of CbAEs render them potential candidates for the development of novel transmission control strateg...

Therapeutic potential for amyloid surface inhibitor: Only Amyloid-β oligomers formed by secondary nucleation disrupt lipid membrane integrity

Engineered extracellular vesicles and their mimics in cardiovascular diseases

We believe this Review can provide some new insights on engineering EVs and EV mimics and facilitate their application in precise control of CVDs....

A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV

Our results reveal a mechanism that contributes to COVID-19 pathogenesis in the diabetic population and suggest that 1,5-AG supplementation may be ben...

Stereodivergent total synthesis of rocaglaol initiated by synergistic dual-metal-catalyzed asymmetric allylation of benzofuran-3(2H)-one

•Stereodivergent allylic alkylation of benzofuran-3(2H)-one •Synergistic dual-metal Co(or Ni) and Ir catalysis •Access four stereoisomers with high yi...