Research

Research

Research

CHEN Yuzong

CHEN Yuzong

陈宇综

Institute of Biomedical Health Technology and Engineering

Senior Principal Investigator

chenyuzong@sz.tsinghua.edu.cn

Timeline

  • 2013 - Present

    Tsinghua University Shenzhen International Graduate School         Professor

  • 2007 - 2021

    Department of Pharmacy, National University of Singapore         Professor

  • 2006

    Department of Pharmacy, National University of Singapore         Associate Professor

  • 2004 - 2005

    National University of Singapore         Head of Dept of Computational Science

  • 1997 - 2005

    Department of Computational Science, National University of Singapore         Assistant Professor/Associate Professor

  • 1997

    Ionis Pharmaceuticals         Scientist

  • 1996 - 1997

    University of Toledo         Visiting Assistant Professor

  • 1989 - 1996

    Purdue University         Postdoc

  • 1985–1989

    University of Manchester, UK         PhD

  • 1982–1985

    Institute of Theoretical Physics, Chinese Academy of Sciences         MSc

  • 1978 - 1982

    Dalian University of Technology         BSc








Research Areas


1. AI in biomedical applications

2. Bioinformatics

3. Computer aided drug design

4. Science and arts (protein art, protein music)












Highlights


  • - Invented inverse docking method for target discovery

  • - Developed the popular therapeutic target database TTD

  • - One of the pioneers in machine learning drug discovery and biological research

  • - Successfully predicted clinical success of drug targets

  • - Discovered clustered patterns of nature-derived drugs

 

Research indicators: H-Index 49 (SCI), 52 (Scopus), Citations: 8940 (SCI), 9761 (Scopus) 


The MolMap object generation







Honors


Outstanding Scientist Award 2007, Science Faculty, National University of Singapore






Related News


- Paper on topic of 'out-of-the-box deep learning prediction of pharmaceutical properties'  was published by Nature sub-journals. Click here to read. 






Selected Publications


(1) Shen, Wanxiang;  Zeng, Xian;  Zhu, Feng;  Wang, Yali;  Qin, Chu;  Tan, Ying;  Jiang, Yuyang*; Chen, Yuzong*, Out-of-the-box deep learning prediction of pharmaceutical properties by broadly learned knowledge-based molecular representations. Nat. Mach. Intell., 2021, 3 (4), 334-343.

(2) Li, Yinghong;  Li, Xiaoxu;  Hong, Jiajun;  Wang, Yunxia;  Fu, Jianbo;  Yang, Hong;  Yu, Chunyan;  Li, Fengcheng;  Hu, Jie;  Xue, Weiwei;  Jiang, Yuyang;  Chen, Yuzong*; Zhu, Feng*, Clinical trials, progression-speed differentiating features and swiftness rule of the innovative targets of first-in-class drugs. Briefings in Bioinformatics, 2020, 21 (2), 649-662.

(3) Zeng, Xian;  Zhang, Peng;  Wang, Yali;  Qin, Chu;  Chen, Shangying;  He, Weidong;  Tao, Lin;  Tan, Ying;  Gao, Dan;  Wang, Bohua;  Chen, Zhe;  Chen, Weiping*;  Jiang, Yuyang*; Chen, Yuzong*, CMAUP: a database of collective molecular activities of useful plants. Nucleic Acids Research, 2019, 47 (D1), D1118-D1127.

(4) Feng Zhu, Xiaoxu Li, Shengyong Yang, Yuzong Chen*. Clinical Success of Drug Targets Prospectively Predicted by In Silico Study. Trends Pharmacol Sci 39(3):229-231. (2018)

Zeng, Xian;  Zhang, Peng;  He, Weidong;  Qin, Chu;  Chen, Shangying;  Tao, Lin;  Wang, Yali;  Tan, Ying;  Gao, Dan;  Wang, Bohua;  Chen, Zhe;  Chen, Weiping*;  Jiang, Yuyang*; Chen, Yuzong*, NPASS: natural product activity and species source database for natural product research, discovery and tool development. Nucleic Acids Research, 2018, 46 (D1), D1217-D1222. 






Openings


1. Assistant Investigator

https://www.szbl.ac.cn/careers/recruitment/502.html


2. Postdoc

https://www.szbl.ac.cn/careers/recruitment/503.html


3. Research Assistant

https://www.szbl.ac.cn/careers/recruitment/504.html