Research

Research

Research

MA Lan

MA Lan

马岚

Institute of Biomedical Health Technology and Engineering

Senior Principal Investigator


malan@sz.tsinghua.edu.cn

Timeline

  • 2019 - Present

    Shenzhen Bay Laboratory         Senior Principal Investigator

  • 2014 - Present

    Tsinghua Shenzhen International Graduate School         Associate Dean

  • 2013 - 2014

    Tsinghua Shenzhen International Graduate School         Director, Research Office

  • 2012 - Present

    Shenzhen Innovative Nano-Diagnostic Reagents Engineering Laboratory         Laboratory Chief

  • 2011 - Present

    Tsinghua Shenzhen International Graduate School         Professor

  • 2005 - 2011

    Tsinghua Shenzhen International Graduate School         Associate Professor

  • 2000 - 2005

    Yunnan University         Associate Professor

  • 1997 - 1998

    University of Wisconsin         Visiting Scholar

  • 1995 - 2000

    School of Life Sciences, Yunnan University         Lecturer

  • 2003

    Kunming Institute of Zoology         PhD

  • 1993 - 1995

    School of Life Sciences, Yunnan University         Teaching Assistant

  • 1993

    Peking University         MSc

  • 1987 - 1990

    Kunming Institute of Zoology, The Chinese Academy of Sciences         Assistant Scientist

  • 1987

    Wuhan University         BS











Research Areas


Prof. Ma’s research interests various aspects including the development of novel nanodiagnostic agents and antibody drugs, stem cell biology and vaccine engineering. Recent research in her laboratory utilizes bioinformatics, phage display, multi-omics and Mueller polarimetric imaging to identify new biomarkers of breast cancer, lung cancer and glioma. Her laboratory is also investigating in vivo theranostics and targeted therapy by using non-toxic nanomaterials including 3-helix micelle, carbon dots and graphene. 












Highlights


Prof. Ma has been devoted to the research and development of rapid immunochromatographic detection for years. She has established a self-dependent innovative platform for ultrasensitive, quantitative, multi-index nano rapid detection. She is the principal investigator and co-principal investigator of more than 40 national, ministerial, provincial and municipal research projects. Prof. Ma has published over 70 papers, obtained 30 issued patents, and participated in formulating 6 national and industry standards. Prof. Ma has developed several products for major disease detection. The fluorescent reagent co-developed with industry for rapid detection of influenza A and B obtained the Class III medical device certificate issued by CFDA in October 2018.


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We developed a quantum dot-based lateral flow immunoassay system (QD-LFIAS) to detect influenza A virus subtypes both H5 and H9. In this design, antibodies of influenza A virus subtypes H5 and H9 were covalently attached to fluorescent tags-quantum dots (QDs). Once influenza A virus subtype H5 or H9 was added to the QD-LFIAS, it would be captured by the coating antibodies on QDs at test line 1 or 2 to form a sandwich complex. This complex produced a bright fluorescent band under 365 nm ultraviolet excitation. The intensity of fluorescence could be detected by using an inexpensive, low-maintenance instrument, and the virus concentration directly correlating with the fluorescence intensity. The detection limits of the QD-LFIAS for influenza A virus subtypes H5 and H9 were 0.016 HAU and 0.25 HAU, respectively. Detection results of H5 and H9 were performed with excellent specificity and reproducibility. The simple analysis procedure and quick test (<15 min) indicate that the QD-LFIAS is a highly-efficient test and can be used to monitor Influenza A virus subtypes H5 and H9 simultaneously.












Honors


2019    The second prize of Guangdong Science and Technology Award

2006    China Standard Innovation Award, Standardization Administration of China

2004    National innovation expert, China Federation of Trade Unions

2003    2003 China Economic Women of the Year, China Women's Federation

2002    New century women's outstanding inventor, China Women's Federation and China Intellectual Property Office

2002    National "three eight" red banner pacesetter, China Women's Federation








Selected Publications


1. Liu Bin; Yao Yue; Liu Ruiqi; Ma Hui*; Ma Lan*. Mueller polarimetric imaging for characterizing the collagen microstructures of breast cancer tissues in different genotypes. Optics Communications, 2019, Vol. 433, 60-67.

 

2. Li, J., Mao, M., Wu, F., Li, Q., Wei, L., & Ma, L. Amino-functionalized CdSe/ZnS quantum dot-based lateral flow immunoassay for sensitive detection of aflatoxin B1. Analytical Methods, 2018, 10(29), 3582–3588.

 

3. Feng Wu, Mao Mao, Yu Cen, Hongtian Yang, Zhifeng Qin and Lan Ma*. Copolymerization of Eu (TTA)3Phen doped styrene and methyl methacrylate nanoparticles and use in quantitative detection of pepsinogen. RSC Adv., 2017,7:12217-12223.

 

4. Yiwei Shu, Ho Nam Chan, Dongshi Guan, Hongkai Wu*, Lan M*. A simple fabricated thickness-based stiffness gradient for cell studies. Science Bulletin., 2017, 62(3): 222-228.

 

5. Feng Wu, Hang Yuan, Changhua Zhou, Mao Mao, Qian Liu, Huaibin Shen, Yu Cen, Zhifeng Qin, Ling Song Li*, Lan Ma*. Multiplexed detection of influenza A virus subtype H5 and H9 via quantum DoT-based immunoassay. Biosensors and Bioelectronic., Biosensors and Bioelectronics., 2016, 77: 464-470.