Persistence makes miracles！
Institute of Molecular Physiology
Junior Principal Investigator
Home page of research group：www.deng-lab.net
2020 - Present
Shenzhen Bay Laboratory Junior Principal Investigator
2015 - 2020
Harvard Medical School & Dana-Farber Cancer Institute & Howard Hughes Medical Institute Research Fellow
2010 - 2015
Dartmouth College Ph.D.
2008 - 2010
Northwest Agriculture & Forestry University M.S.
2004 - 2008
Northwest Agriculture & Forestry University B. S.
The Deng laboratory is interested in cell cycle regulation and genome instability. We use a combination of cutting-edge techniques such as in vitro biochemical reconstitution, genome engineering, high throughput live-cell imaging, genome sequencing and so forth, to address how cells coordinate growth and division under normal and pathological conditions such as cancer.
Dr. Lin Deng has a long-standing interest in cell cycle regulation and genome instability. He obtained his Ph.D. in Biochemistry from Dartmouth College in U.S., supervised by Dr. James Moseley. His Ph.D. work dissected the signaling pathways for G2/M transition and discovered many novel factors and sub-cellular structures that regulate cell growth and division. Dr. Deng received his postdoc training at Harvard Medical School and Dana Farber Cancer Institute, jointly supervised by Dr. David Pellman and Joahnnes Walter. His postdoc research revealed novel mechanisms of genome instability induced by DNA replication stress and cell cycle defects.
Dr. Deng’s research has been published in peer-reviewed journals such as Molecular Cell, Current Biology, Molecular Biology of the Cell, Molecular and Cellular Biology, and so forth. These works have been recognized by several awards including The International Youth Friend of Shenzhen, China (2017), E. Lucile Smith Award for Excellence in Biochemistry, Dartmouth Medical School (2015), Chinese Government Award for Outstanding Students Abroad (2014), and John H. Copenhaver, Jr. and William H. Thomas, MD 1952 Fellow, Dartmouth College (2014).
Mechanism of genome instability caused by premature mitosis
• 2020 Oversea High-caliber Personnel, Shenzhen, China
• 2017 The International Youth Friend of Shenzhen City, China
• 2015 Chinese Government Award for Outstanding Students Abroad
• 2015 E. Lucile Smith Award for Excellence in Biochemistry, Dartmouth Medical School
• 2014 - 2015 John H. Copenhaver, Jr. and William H. Thomas, MD 1952 Fellow, Dartmouth College
1. Deng, L., Wu, R.A., Sonneville, R., Kochenova, O.V., Labib, K., Pellman, D., and Walter, J.C. (2019). Mitotic CDK promotes replisome disassembly, fork collapse, and complex DNA rearrangements. Molecular Cell, 73(5):915-929.e6. PMID:30849395.
** Recommended by F1000 in Cell Biology
2. Deng, L., Lee, M.E. Schutt K.L., and Moseley, J.B. (2017). Phosphatases generate signal specificity downstream of Ssp1 kinase in fission yeast. Molecular and Cellular Biology, 37:e00494-16.doi: 10.1128/MCB.00494-16. PMID: 28223368.
3. Deng, L., Baldissard, S., Kettenbach, A.N., Gerber, S.A., and Moseley, J.B. (2014). Dueling kinases regulate cell size at division through the SAD kinase Cdr2. Current Biology 24, 428-433. PMID: 24508166.
4. Deng, L., Kabeche, R., Wang, N., Wu, J.-Q., and Moseley, J.B. (2014). Megadalton node assembly by binding of Skb1 to the membrane anchor Slf1. Molecular Biology of the Cell 25, 2660-2668. PMID: 25009287.
** A highlight from MBoC Selection; Highlighted in October 2014 ASCB Newsletter
** A highlight from MBoC Selection; Highlighted in July 2013 ASCB Newsletter